In a longitudinal study of their health and development, 384 15-year-old females reported their experience of symptoms indicative of premenstrual syndrome (PMS). The prevalence of these symptoms is reported and a group of adolescents is identified with the syndrome (14%). PMS was associated with current self-reported anxiety, inattention, and poor health. Preadolescent self-report and maternal ratings of physical and mental health did not significantly predict adolescent PMS. The results suggest that the experience of PMS in adolescence may be mediated by perceived health status; the roles of mental health and maternal influence in the development of adolescent PMS may be minimal.