Abstract
MRI was performed in 21 patients and single photon emission computed tomography (SPECT) with N-isopropyl-p-123I iodoamphetamine in 16 patients, to visualize upper motor neurone lesions in amyotrophic lateral sclerosis. T2-weighted MRI revealed high signal along the course of the pyramidal tract in the internal capsule and cerebral peduncle in 4 of 21 patients. SPECT images were normal in 4 patients, but uptake was reduced in the cerebral cortex that includes the motor area in 11.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Amphetamines
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Amyotrophic Lateral Sclerosis / diagnosis*
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Amyotrophic Lateral Sclerosis / diagnostic imaging*
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Amyotrophic Lateral Sclerosis / physiopathology
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Brain / diagnostic imaging*
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Brain / pathology*
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Female
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Frontal Lobe / diagnostic imaging
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Frontal Lobe / pathology
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Gyrus Cinguli / diagnostic imaging
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Gyrus Cinguli / pathology
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Humans
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Iodine Radioisotopes
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Iofetamine
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Magnetic Resonance Imaging*
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Male
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Mesencephalon / diagnostic imaging
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Mesencephalon / pathology
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Middle Aged
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Motor Cortex / diagnostic imaging
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Motor Cortex / pathology
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Motor Neurons / diagnostic imaging*
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Motor Neurons / pathology*
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Nerve Fibers, Myelinated / diagnostic imaging
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Nerve Fibers, Myelinated / pathology
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Pyramidal Tracts / diagnostic imaging
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Pyramidal Tracts / pathology
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Reflex, Stretch / physiology
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Tomography, Emission-Computed, Single-Photon*
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Wallerian Degeneration
Substances
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Amphetamines
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Iodine Radioisotopes
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Iofetamine