Hairy cell leukemia and factor VIII inhibitor: a case report

Nouv Rev Fr Hematol (1978). 1992;34(3):269-71.

Abstract

Acquired factor VIII inhibitors are usually described in hemophilia A, although some cases have been documented in chronic inflammatory diseases and malignant tumors. We report here the first case of a factor VIII inhibitor appearing in the course of hairy cell leukemia. Interferon therapy over a 5 month period led to complete remission of leukemia with parallel disappearance of the acquired factor VIII inhibitor.

Publication types

  • Case Reports

MeSH terms

  • Factor VIII / antagonists & inhibitors*
  • Humans
  • Interferon-alpha / therapeutic use
  • Leukemia, Hairy Cell / blood*
  • Leukemia, Hairy Cell / therapy
  • Male
  • Middle Aged
  • Remission Induction / methods

Substances

  • Interferon-alpha
  • Factor VIII