Inhibition of hepatic and cutaneous biotransformation of resorufin ethers following intraperitoneal administration of 1-aminobenzotriazole

Pharm Res. 1992 Aug;9(8):1099-102. doi: 10.1023/a:1015827100111.

Authors

N F Oldfield¹, M Mortillo, W A Garland, B A Mico

Affiliation

¹ Department of Drug Metabolism, Hoffmann-La Roche, Nutley, New Jersey 07110.

PMID: 1409385
DOI: 10.1023/a:1015827100111

No abstract available

MeSH terms

Animals
Biotransformation / drug effects
Cytochrome P-450 Enzyme System / metabolism
Dealkylation
Ethers / pharmacokinetics
Injections, Intraperitoneal
Male
Mice
Microsomes, Liver / drug effects
Microsomes, Liver / metabolism*
Oxazines / metabolism
Oxazines / pharmacokinetics*
Skin / drug effects
Skin / metabolism*
Triazoles / administration & dosage
Triazoles / pharmacology*

Substances

Ethers
Oxazines
Triazoles
1-aminobenzotriazole
resorufin
Cytochrome P-450 Enzyme System