Multicentric reticulohistiocytosis. Immunohistological and ultrastructural study: a pathology of dendritic cell lineage

C Perrin; J P Lacour; J F Michiels; P Flory; G Ziegler; J P Ortonne

Multicentric reticulohistiocytosis. Immunohistological and ultrastructural study: a pathology of dendritic cell lineage

Am J Dermatopathol. 1992 Oct;14(5):418-25.

Authors

C Perrin¹, J P Lacour, J F Michiels, P Flory, G Ziegler, J P Ortonne

Affiliation

¹ Department of Pathology, University of Nice, France.

PMID: 1415960

Abstract

A case of multicentric reticulohistiocytosis is presented with extensive immunohistochemical study of the infiltrate in both paraffin and cryostat sections. Factor XIIIa dermal dendrocyte marker was demonstrated in the cytoplasm of histiocytes, which has not been reported previously in this disease. In addition, the S100 protein stained positive. This immunophenotyping study suggests a dermal dendrocyte lineage with an unusual expression of S100 protein.

Publication types

Case Reports

MeSH terms

Dendritic Cells / pathology*
HLA-DR Antigens / analysis
Histiocytosis, Non-Langerhans-Cell / immunology
Histiocytosis, Non-Langerhans-Cell / metabolism
Histiocytosis, Non-Langerhans-Cell / pathology*
Humans
Immunohistochemistry
Immunophenotyping
Lymphocyte Subsets
Male
Middle Aged
Phosphopyruvate Hydratase / analysis
S100 Proteins / analysis
Skin / chemistry
Skin / immunology
Skin / ultrastructure
Skin Diseases / immunology
Skin Diseases / metabolism
Skin Diseases / pathology*

Substances

HLA-DR Antigens
S100 Proteins
Phosphopyruvate Hydratase