Abstract
Recent studies have provided insights into how the complex structure of the T-cell antigen receptor relates to its signal transduction function. Both the CD3 and zeta subunits contain functioning signaling modules that regulate the activation of tyrosine kinases and phosphorylation of cellular substrates.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Humans
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Molecular Sequence Data
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Protein-Tyrosine Kinases / physiology
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Receptor-CD3 Complex, Antigen, T-Cell / chemistry
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Receptors, Antigen, T-Cell / chemistry
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Receptors, Antigen, T-Cell / physiology*
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Signal Transduction / physiology*
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Structure-Activity Relationship
Substances
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Receptor-CD3 Complex, Antigen, T-Cell
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Receptors, Antigen, T-Cell
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Protein-Tyrosine Kinases