Wegener's granulomatosis in a patient with a rheumatoid arthritis

Intern Med. 1992 Sep;31(9):1128-31. doi: 10.2169/internalmedicine.31.1128.

Abstract

A 38-year-old woman with rheumatoid arthritis who developed Wegener's granulomatosis is described. Wegener's granulomatosis appeared with saddle nose, perforation in her nasal septum, and granuloma in the nasal cavity. Laboratory evaluation showed a positive rheumatoid factor and circulating immune complex. Radiographic examination revealed ankylotic changes in both wrist and elbow joints. Bilateral anosmia and other disease manifestations completely responded to treatment with oral cyclophosphamide and prednisolone.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antigen-Antibody Complex / blood
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Arthritis, Rheumatoid / complications*
  • Cyclophosphamide / administration & dosage
  • Female
  • Granulomatosis with Polyangiitis / complications*
  • Granulomatosis with Polyangiitis / drug therapy
  • Granulomatosis with Polyangiitis / pathology
  • Humans
  • Olfaction Disorders / drug therapy
  • Olfaction Disorders / etiology
  • Prednisolone / administration & dosage
  • Rheumatoid Factor / blood

Substances

  • Antigen-Antibody Complex
  • Cyclophosphamide
  • Rheumatoid Factor
  • Prednisolone