Abstract
Two patients with prolonged postictal encephalopathy lasting 63 and 72 hours, respectively, following seizures with clozapine are reported. Clozapine alters the EEG in a majority of patients treated, with seizure frequency as high as 5-10% in doses above 600 mg/d. Prolonged postictal encephalopathy following a clozapine-induced seizure has not been previously reported but may be an important side effect of this medication. Pharmacologic and clinical issues are discussed.
Publication types
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Case Reports
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Adult
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Bipolar Disorder / drug therapy*
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Bipolar Disorder / physiopathology
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Bipolar Disorder / psychology
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Cerebral Cortex / drug effects
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Cerebral Cortex / physiopathology
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Clozapine / adverse effects*
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Clozapine / therapeutic use
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Delta Rhythm
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Electroencephalography / drug effects*
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Epilepsy, Tonic-Clonic / chemically induced*
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Epilepsy, Tonic-Clonic / physiopathology
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Epilepsy, Tonic-Clonic / psychology
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Follow-Up Studies
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Humans
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Male
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Psychoses, Substance-Induced / physiopathology*
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Psychoses, Substance-Induced / psychology
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Schizophrenia, Paranoid / drug therapy*
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Schizophrenia, Paranoid / physiopathology
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Schizophrenia, Paranoid / psychology