Abstract
Hydroxythiamin was shown to inhibite distinctly phosphofructokinase and phosphohexoisomerase besides a direct antivitaminous effect on transketolase. In this case the regulatory action is likely to be carried out by erythrose-4-phosphate, accumulating in liver tissue. Citrate (administered separately and together with hydroxythiamin) is assumed to influence indirectly the transketolase activity affecting the total regulation of carbohydrate metabolism.
MeSH terms
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Animals
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Brain / enzymology
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Citrates / pharmacology*
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Drug Interactions
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Glucose-6-Phosphate Isomerase / antagonists & inhibitors
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Glucosephosphate Dehydrogenase / metabolism
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Glycolysis / drug effects*
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Liver / enzymology
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Myocardium / enzymology
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Oxythiamine / pharmacology*
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Pentosephosphates / metabolism*
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Phosphofructokinase-1 / antagonists & inhibitors
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Phosphogluconate Dehydrogenase / metabolism
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Rats
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Thiazoles / pharmacology*
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Transketolase / antagonists & inhibitors
Substances
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Citrates
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Pentosephosphates
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Thiazoles
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Oxythiamine
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Phosphogluconate Dehydrogenase
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Glucosephosphate Dehydrogenase
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Transketolase
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Phosphofructokinase-1
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Glucose-6-Phosphate Isomerase