A physical map of a 1.3-Mb region on the long arm of chromosome 12, spanning the GLI and LRP loci

A Forus; O Myklebost

doi:10.1016/s0888-7543(05)80292-7

A physical map of a 1.3-Mb region on the long arm of chromosome 12, spanning the GLI and LRP loci

Genomics. 1992 Sep;14(1):117-20. doi: 10.1016/s0888-7543(05)80292-7.

Authors

A Forus¹, O Myklebost

Affiliation

¹ Department of Tumor Biology, Norwegian Radium Hospital, Montebello, Oslo.

PMID: 1427818
DOI: 10.1016/s0888-7543(05)80292-7

Abstract

We have used pulsed-field gel electrophoresis to construct a long-range restriction map spanning more than 1.3 million bp of the q13-q14 segment of chromosome 12. Within this region lie the genes coding for the gli oncogene and the low-density lipoprotein receptor-related protein (LRP). The distance between the genes is about 200-300 kb. We also observe a methylation-free island 3' to the LRP gene.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosomes, Human, Pair 12*
Electrophoresis, Gel, Pulsed-Field
Humans
Low Density Lipoprotein Receptor-Related Protein-1
Membrane Proteins
Nucleic Acid Hybridization
RNA Probes
Receptors, Immunologic / genetics*
Restriction Mapping*
Zinc Fingers / genetics*

Substances

Low Density Lipoprotein Receptor-Related Protein-1
Membrane Proteins
RNA Probes
Receptors, Immunologic