Abstract
Complete toxicological examinations in female rats fed an "anti-inflammatory" 200 ppm copper-containing diet for 30 and 58 days were performed. Copper was found to accumulate in liver, kidneys and paws; however, at the hematological, clinical chemical and histopathological levels, this treatment did not seem able to induce any toxic accumulation phenomenon in the examined rats.
MeSH terms
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Alkaline Phosphatase / blood
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Animals
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Blood Cell Count / drug effects
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Brain / drug effects
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Brain / metabolism
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Copper / administration & dosage*
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Copper / blood
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Copper / pharmacokinetics
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Creatinine / blood
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Diet
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Female
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Hindlimb / metabolism
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Kidney / drug effects
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Kidney / metabolism*
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Liver / drug effects
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Liver / metabolism*
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Rats
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Rats, Sprague-Dawley
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Transaminases / blood
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Urea / blood
Substances
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Copper
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Urea
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Creatinine
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Transaminases
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Alkaline Phosphatase