Abstract
The synthesis and neuropsychopharmacological properties of new 1,3,4,14b-tetrahydro-2H,10H-pyrazino [2,1-d] pyrrolo [1,2-b] [1,2,5] benzotriazepine derivatives related to antidepressant agent aptazepine are reported. The new derivatives displayed sedative-miorelaxant activity in mice, but no significant antagonist effect on clonidine blockade of phenylquinone-induced abdominal constriction. Among test compounds 4a, 4l and 4n showed high antinociceptive effect on the hot-plate test and compound 4e protected from death and convulsion all the electroshocked animals.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analgesics / chemical synthesis
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Analgesics / pharmacology
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Animals
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Anticonvulsants / chemical synthesis
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Anticonvulsants / pharmacology
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Benzazepines / chemical synthesis*
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Benzazepines / pharmacology
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Benzoquinones
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Clonidine / antagonists & inhibitors
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Clonidine / pharmacology
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Cricetinae
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Exploratory Behavior / drug effects
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Female
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Male
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Mice
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Motor Activity / drug effects
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Muscle Relaxants, Central / chemical synthesis
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Muscle Relaxants, Central / pharmacology
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Pain / chemically induced
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Psychotropic Drugs / chemical synthesis*
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Psychotropic Drugs / pharmacology
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Spectrophotometry, Infrared
Substances
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Analgesics
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Anticonvulsants
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Benzazepines
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Benzoquinones
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Muscle Relaxants, Central
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Psychotropic Drugs
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phenylbenzoquinone
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Clonidine