Abstract
Nerve regeneration across peripheral nerve allografts and control autografts in primates immunosuppressed with Cyclosporin A was quantitatively evaluated by electrophysiologic and histologic methods. Twelve cynomolgus monkeys received 3-cm autografts and allografts in contralateral ulnar nerves. They were immunosuppressed with Cyclosporin A at 25 mg/kg per day or placebo vehicle. Morphometric analysis of nerve graft and distal nerve segments was assessed at 1 year after engraftment. Quantitative electrophysiologic studies were performed percutaneously at 6 and 12 months, and compound action potentials were measured directly across the nerve grafts at 1 year. Excellent regeneration was seen across autografts and allografts in Cyclosporin A-treated and placebo-treated recipients.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Action Potentials / physiology
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Animals
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Cyclosporine / administration & dosage
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Cyclosporine / therapeutic use*
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Electromyography
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Graft Rejection
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Histocompatibility Antigens Class I / analysis
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Immunocompromised Host*
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Lymphocytes / immunology
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Macaca fascicularis
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Male
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Motor Neurons / pathology
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Motor Neurons / physiology
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Nerve Fibers / pathology
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Nerve Fibers / physiology
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Nerve Regeneration / physiology
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Neural Conduction / physiology
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Placebos
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Prospective Studies
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Random Allocation
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Sural Nerve / pathology
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Sural Nerve / physiopathology
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Sural Nerve / transplantation*
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Transplantation, Autologous
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Transplantation, Homologous
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Ulnar Nerve / pathology
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Ulnar Nerve / physiopathology
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Ulnar Nerve / surgery
Substances
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Histocompatibility Antigens Class I
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Placebos
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Cyclosporine