Defining control: regulation of dendritic cell activation and immune homeostasis by SOCS1

Robyn Starr; Douglas J Hilton

doi:10.1016/s1074-7613(03)00243-7

Defining control: regulation of dendritic cell activation and immune homeostasis by SOCS1

Immunity. 2003 Sep;19(3):308-9. doi: 10.1016/s1074-7613(03)00243-7.

Authors

Robyn Starr¹, Douglas J Hilton

Affiliation

¹ The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.

PMID: 14499106
DOI: 10.1016/s1074-7613(03)00243-7

Abstract

SOCS1 is a key regulator of cytokine signaling and is important for maintaining balance in the immune system. In addition to roles in T, NKT, and macrophage cell function, a new study indicates that SOCS1 modulates dendritic cell activation and may help prevent autoimmunity.

Publication types

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MeSH terms

Animals
Carrier Proteins / metabolism*
Cytokines / metabolism
Dendritic Cells / metabolism*
Homeostasis / physiology*
Immune System / metabolism*
Mice
Repressor Proteins*
Signal Transduction / physiology
Suppressor of Cytokine Signaling 1 Protein
Suppressor of Cytokine Signaling Proteins

Substances

Carrier Proteins
Cytokines
Repressor Proteins
Socs1 protein, mouse
Suppressor of Cytokine Signaling 1 Protein
Suppressor of Cytokine Signaling Proteins