Synthesis of novel C2 and C2-C8 linked pyrrolo[2,1-c][1,4]benzodiazepine-naphthalimide hybrids as DNA-binding agents

Ahmed Kamal; O Srinivas; P Ramulu; G Ramesh; P Praveen Kumar

doi:10.1016/s0960-894x(03)00718-2

Synthesis of novel C2 and C2-C8 linked pyrrolo[2,1-c][1,4]benzodiazepine-naphthalimide hybrids as DNA-binding agents

Bioorg Med Chem Lett. 2003 Oct 20;13(20):3577-81. doi: 10.1016/s0960-894x(03)00718-2.

Authors

Ahmed Kamal¹, O Srinivas, P Ramulu, G Ramesh, P Praveen Kumar

Affiliation

¹ Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India. [email protected]

PMID: 14505674
DOI: 10.1016/s0960-894x(03)00718-2

Abstract

Synthesis of C2 and C2-C8 linked pyrrolobenzodiazepine-naphthalimide hybrids have been prepared that exhibit significant DNA-binding affinity and cytotoxicity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Benzodiazepines / chemistry*
Benzodiazepines / metabolism
DNA / metabolism
Imides / chemistry*
Imides / metabolism
Naphthalenes / chemistry*
Naphthalenes / metabolism
Pyrroles / chemistry*
Pyrroles / metabolism

Substances

Imides
Naphthalenes
Pyrroles
pyrrolo(2,1-c)(1,4)benzodiazepine
Benzodiazepines
DNA