The hepatitis B virus X protein transactivation of c-fos and c-myc proto-oncogenes is mediated by multiple transcription factors

M L Avantaggiati; C Balsano; G Natoli; E De Marzio; H Will; E Elfassi; M Levrero

doi:10.1007/978-3-7091-5633-9_12

The hepatitis B virus X protein transactivation of c-fos and c-myc proto-oncogenes is mediated by multiple transcription factors

Arch Virol Suppl. 1992:4:57-61. doi: 10.1007/978-3-7091-5633-9_12.

Authors

M L Avantaggiati¹, C Balsano, G Natoli, E De Marzio, H Will, E Elfassi, M Levrero

Affiliation

¹ I Clinica Medica, Fondazione Andrea Cesalpino Policlinico Umberto I, Rome, Italy.

PMID: 1450726
DOI: 10.1007/978-3-7091-5633-9_12

Abstract

We have constructed two expression vectors in order to study the action of the HBV 17 Kd X protein on the c-fos and c-myc promoters. The results show that the promoters contain multiple elements that respond to X protein, suggesting involvement of multiple transcription factors. The exact mechanism of the interaction remains elusive, but our data allow speculation about the factors that may be influenced.

MeSH terms

Chloramphenicol O-Acetyltransferase / genetics
DNA Mutational Analysis
Genes, fos / genetics*
Genes, myc / genetics*
Genetic Vectors / genetics
Hepatitis B virus / genetics*
Promoter Regions, Genetic / genetics
Recombinant Fusion Proteins
Transcription Factors / genetics*
Transcriptional Activation*

Substances

Recombinant Fusion Proteins
Transcription Factors
Chloramphenicol O-Acetyltransferase