Lack of pre-C region mutation in woodchuck hepatitis virus from seroconverted woodchucks

S P Tong; L Vitvitski; J S Li; C Pichoud; C Trépo

doi:10.1007/978-3-7091-5633-9_20

Lack of pre-C region mutation in woodchuck hepatitis virus from seroconverted woodchucks

Arch Virol Suppl. 1992:4:95-6. doi: 10.1007/978-3-7091-5633-9_20.

Authors

S P Tong¹, L Vitvitski, J S Li, C Pichoud, C Trépo

Affiliation

¹ INSERM U.271, Lyon, France.

PMID: 1450731
DOI: 10.1007/978-3-7091-5633-9_20

Abstract

Woodchuck hepatitis virus, which shares a large degree of homology with human HBV, was examined for indications of mutational variants. No alteration in the pre-C region was found, but as in HBV, viral DNA could still be detected by PCR after seroconversion to anti-WHe.

MeSH terms

Animals
Antibodies, Viral / blood
Hepadnaviridae / genetics*
Hepatitis B e Antigens / genetics*
Hepatitis, Viral, Animal / genetics*
Hepatitis, Viral, Animal / immunology
Marmota / microbiology*
Mutagenesis
Polymerase Chain Reaction
Viral Core Proteins / genetics*

Substances

Antibodies, Viral
Hepatitis B e Antigens
Viral Core Proteins