Synthesis and properties of oligonucleotides containing C-2 and/or C-5 substituted arabinofuranosyluracils

Hiroaki Ozaki; Kiyohiro Nakajima; Kyoko Yajima; Kaoru Tatsui; Masayasu Kuwahara; Hiroaki Sawai

doi:10.1093/nass/3.1.59

Synthesis and properties of oligonucleotides containing C-2 and/or C-5 substituted arabinofuranosyluracils

Nucleic Acids Res Suppl. 2003:(3):59-60. doi: 10.1093/nass/3.1.59.

Authors

Hiroaki Ozaki¹, Kiyohiro Nakajima, Kyoko Yajima, Kaoru Tatsui, Masayasu Kuwahara, Hiroaki Sawai

Affiliation

¹ Department of Chemistry, Faculty of Engineering, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan.

PMID: 14510379
DOI: 10.1093/nass/3.1.59

Abstract

The oligodeoxyribonucleotides (ODN) containing C-2 and/or C-5 substituted arabinofuranosyluracils were synthesized by a post-synthetic modification method. The duplex stability of the ODN bearing isocytosine derivative with DNA was lower than that of the normal ODN/DNA duplex but the ODN bearing C5-substituted uracil derivative was similar to the normal ODN/DNA duplex.

MeSH terms

Arabinofuranosyluracil / chemistry*
Base Sequence
Oligonucleotides / chemical synthesis
Oligonucleotides / chemistry*
Spectrometry, Mass, Electrospray Ionization

Substances

Oligonucleotides
Arabinofuranosyluracil