Abstract
The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adaptor Proteins, Signal Transducing
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Animals
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Antigen-Presenting Cells / immunology
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Antigens / immunology
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Cell Membrane / immunology
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Cell Membrane / metabolism
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Computer Simulation
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Cytoskeletal Proteins
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Down-Regulation
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Endocytosis
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Ligands
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Lipid Bilayers
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Lymphocyte Activation*
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Major Histocompatibility Complex
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Mice
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Mice, Transgenic
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Microscopy, Confocal
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Models, Immunological
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Monte Carlo Method
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Peptides / immunology
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Peptides / metabolism
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Phosphorylation
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Protein-Tyrosine Kinases / metabolism
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Proteins / metabolism
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Receptor Aggregation
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Receptors, Antigen, T-Cell / immunology
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Receptors, Antigen, T-Cell / metabolism*
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Signal Transduction*
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T-Lymphocytes / immunology*
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T-Lymphocytes / metabolism
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ZAP-70 Protein-Tyrosine Kinase
Substances
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Adaptor Proteins, Signal Transducing
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Antigens
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CD2-associated protein
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Cytoskeletal Proteins
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Ligands
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Lipid Bilayers
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Peptides
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Proteins
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Receptors, Antigen, T-Cell
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Protein-Tyrosine Kinases
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ZAP-70 Protein-Tyrosine Kinase
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Zap70 protein, mouse