No evidence for DUP25 in patients with panic disorder using a quantitative real-time PCR approach

Johannes Schumacher; Andreas C J Otte; Tim Becker; Yuli Sun; Thomas F Wienker; Brunhilde Wirth; Petra Franke; Rami Abou Jamra; Peter Propping; Jürgen Deckert; Markus M Nöthen; Sven Cichon

doi:10.1007/s00439-003-1022-5

No evidence for DUP25 in patients with panic disorder using a quantitative real-time PCR approach

Hum Genet. 2003 Dec;114(1):115-7. doi: 10.1007/s00439-003-1022-5. Epub 2003 Sep 25.

Authors

Johannes Schumacher¹, Andreas C J Otte, Tim Becker, Yuli Sun, Thomas F Wienker, Brunhilde Wirth, Petra Franke, Rami Abou Jamra, Peter Propping, Jürgen Deckert, Markus M Nöthen, Sven Cichon

Affiliation

¹ Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, 53111 Bonn, Germany. [email protected]

PMID: 14513359
DOI: 10.1007/s00439-003-1022-5

Abstract

A duplication of chromosome 15q24-q26 (DUP25) has been reported to be associated with anxiety disorders. We tested for the presence of DUP25 in a sample of 50 patients with panic disorder and 50 controls using a quantitative real-time PCR approach. Contrary to the original finding, our results were compatible with the absence of DUP25, and no significant difference could be detected between patients and controls ( P=1.0). Thus, our study does not support the hypothesis of an involvement of DUP25 in panic disorder.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Mapping
Chromosomes, Human, Pair 11 / genetics
Chromosomes, Human, Pair 13 / genetics
Chromosomes, Human, Pair 15 / genetics*
Cyclic AMP Response Element-Binding Protein
Gene Duplication*
Humans
Nerve Tissue Proteins / genetics
Panic Disorder / genetics*
Polymerase Chain Reaction / methods
RNA-Binding Proteins
SMN Complex Proteins

Substances

Cyclic AMP Response Element-Binding Protein
Nerve Tissue Proteins
RNA-Binding Proteins
SMN Complex Proteins