Drop-delay measurement using enzyme-coated particles

Cytometry. 1992;13(6):649-52. doi: 10.1002/cyto.990130614.

Abstract

A simple technique is suggested for the measurement of drop delay for flow sorting. While the flow cytometer was set to sort a fixed number of particles, the drop-delay setting was changed step by step, and at each step the HRP-coupled particles were sorted into a well of an immunoassay strip. Then the HRP activity of the sorted samples was revealed by routine methods. The maximum level of the enzyme activity shows the proper drop-delay setting. Determination of the drop-delay setting takes only a few minutes. The technique is independent of the type of flow cytometer and does not require any additional equipment.

MeSH terms

  • Animals
  • Benzimidazoles
  • Blood Cell Count / instrumentation
  • Blood Cell Count / methods
  • Cell Separation / instrumentation
  • Cell Separation / methods*
  • Flow Cytometry / instrumentation
  • Flow Cytometry / methods*
  • Fluorescein-5-isothiocyanate
  • Horseradish Peroxidase
  • Microscopy, Fluorescence
  • Nephelometry and Turbidimetry
  • Ranidae / blood
  • Time Factors

Substances

  • Benzimidazoles
  • Horseradish Peroxidase
  • Fluorescein-5-isothiocyanate
  • bisbenzimide ethoxide trihydrochloride