Abstract
A growing number of reports describing the association of certain deletions within exon 11 of the RET proto-oncogene with aggressive courses of medullary thyroid carcinoma, point to a potential prognostic relevance of molecular features in the sporadic tumor, analogous to the hereditary variant.
MeSH terms
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Amino Acid Substitution / genetics
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Base Pairing / genetics
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Carcinoma, Medullary / genetics*
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Carcinoma, Medullary / pathology
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Chromosome Deletion*
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Codon
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DNA Mutational Analysis
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Exons
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Humans
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Neoplasm Invasiveness / genetics
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Polymorphism, Single-Stranded Conformational
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Prognosis
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Proto-Oncogene Mas
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Proto-Oncogene Proteins / genetics*
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Proto-Oncogene Proteins c-ret
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Receptor Protein-Tyrosine Kinases / genetics*
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Thyroid Neoplasms / genetics*
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Thyroid Neoplasms / pathology
Substances
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Codon
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MAS1 protein, human
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Proto-Oncogene Mas
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-ret
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Receptor Protein-Tyrosine Kinases