Abstract
Conjugation of surface binding groups with inhibitors for carbonic anhydrase leads to the conversion of weak inhibitors to strong inhibitors.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Binding, Competitive
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Carbonic Anhydrase Inhibitors / chemical synthesis
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Carbonic Anhydrase Inhibitors / chemistry*
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Carbonic Anhydrase Inhibitors / metabolism
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Carbonic Anhydrases / metabolism
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Catalysis
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Histidine / chemistry*
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Kinetics
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Metals, Heavy / chemistry
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Metals, Heavy / metabolism
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Models, Chemical
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Molecular Structure
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Organometallic Compounds / chemistry
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Organometallic Compounds / metabolism
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Protein Binding
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Sulfonamides / chemical synthesis
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Sulfonamides / chemistry*
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Sulfonamides / metabolism
Substances
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Carbonic Anhydrase Inhibitors
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Metals, Heavy
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Organometallic Compounds
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Sulfonamides
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Histidine
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Carbonic Anhydrases