Seasonal differences in the onset of the EBV-positive and -negative forms of paediatric Hodgkin's lymphoma

A Reiman; J E Powell; K J Flavell; R G Grundy; J R Mann; S Parkes; D Redfern; L S Young; P G Murray

doi:10.1038/sj.bjc.6601277

Seasonal differences in the onset of the EBV-positive and -negative forms of paediatric Hodgkin's lymphoma

Br J Cancer. 2003 Oct 6;89(7):1200-1. doi: 10.1038/sj.bjc.6601277.

Authors

A Reiman¹, J E Powell, K J Flavell, R G Grundy, J R Mann, S Parkes, D Redfern, L S Young, P G Murray

Affiliation

¹ Department of Pathology, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Abstract

In this study, we have shown that there are seasonal differences in the onset of the (Epstein-Barr virus) EBV-positive and -negative forms of paediatric Hodgkin's lymphoma (HL). This suggests aetiological differences between the two forms of this disease. EBV-positive HL might be a rare consequence of primary EBV infection.

Publication types

Comparative Study

MeSH terms

Adolescent
Child
Child, Preschool
Epstein-Barr Virus Infections / epidemiology
Epstein-Barr Virus Infections / virology*
Herpesvirus 4, Human / isolation & purification*
Hodgkin Disease / epidemiology
Hodgkin Disease / virology*
Humans
Immunoenzyme Techniques
Infant
Infant, Newborn
Prevalence
Seasons*
United Kingdom / epidemiology
Viral Matrix Proteins / analysis

Substances

EBV-associated membrane antigen, Epstein-Barr virus
Viral Matrix Proteins