Abstract
A series of novel azapyranoxanthenones, bearing structural similarity to the acridone alkaloid acronycine have been designed and synthesized. Their in vitro cytotoxicities against the murine L1210 leukemia and the human solid tumor HT-29 cell lines have been investigated. The new derivatives exhibited interesting cytotoxic activity and were more potent than the parent compound.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acridines / chemistry
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Acridones
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Acronine / analogs & derivatives*
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Acronine / chemistry
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Acronine / toxicity
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / toxicity*
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Cell Cycle Proteins / analysis
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Cell Line, Tumor
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Drug Design
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Drug Screening Assays, Antitumor
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HT29 Cells
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Humans
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Inhibitory Concentration 50
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Leukemia L1210 / drug therapy
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Mice
Substances
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Acridines
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Acridones
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Antineoplastic Agents
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Cell Cycle Proteins
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acridone
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Acronine