DNA repair by bacterial AlkB proteins

Res Microbiol. 2003 Oct;154(8):531-8. doi: 10.1016/S0923-2508(03)00150-5.

Abstract

The Escherichia coli AlkB protein is an iron- and 2-oxoglutarate-dependent oxygenase, repairing 1-methyladenine and 3-methylcytosine lesions in DNA. AlkB homologues are present in a number of bacterial species, and some bacteria have two different AlkB proteins. AlkB also repairs lesions in RNA, and the biological significance of RNA repair is discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenine / analogs & derivatives*
  • Adenine / metabolism
  • Alkylation
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Cytosine / analogs & derivatives*
  • Cytosine / metabolism
  • DNA Repair*
  • Escherichia coli Proteins / genetics
  • Escherichia coli Proteins / metabolism*
  • Mixed Function Oxygenases / genetics
  • Mixed Function Oxygenases / metabolism*
  • Molecular Sequence Data
  • Oxygenases / genetics
  • Oxygenases / metabolism*
  • Phylogeny
  • Sequence Alignment
  • Sequence Homology, Amino Acid

Substances

  • Bacterial Proteins
  • Escherichia coli Proteins
  • 3-methylcytosine
  • 1-methyladenine
  • Cytosine
  • Mixed Function Oxygenases
  • Oxygenases
  • iron(II) oxygenase
  • AlkB protein, E coli
  • Adenine