A polo match for Plk1

Cell. 2003 Oct 3;115(1):3-4. doi: 10.1016/s0092-8674(03)00761-x.

Abstract

New work by Elia et al. in this issue of Cell reveals the molecular basis of phosphopeptide recognition by the polo domain and the domain's dual function to promote substrate recognition by targeting the kinase to subcellular structures and to autoregulate the adjacent protein kinase catalytic domain.

Publication types

  • Comment

MeSH terms

  • Amino Acid Motifs
  • Animals
  • Binding Sites
  • Cell Cycle Proteins
  • Fungal Proteins / chemistry
  • Fungal Proteins / metabolism
  • Humans
  • Phosphopeptides / chemistry
  • Phosphopeptides / metabolism*
  • Polo-Like Kinase 1
  • Protein Kinases / chemistry
  • Protein Kinases / metabolism*
  • Protein Serine-Threonine Kinases
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins

Substances

  • Cell Cycle Proteins
  • Fungal Proteins
  • Phosphopeptides
  • Proto-Oncogene Proteins
  • Protein Kinases
  • Protein Serine-Threonine Kinases