Content of autoantibodies to bradykinin and beta-amyloid(1-42) as a criterion for biochemical differences between Alzheimer's dementias

Bull Exp Biol Med. 2003 Jul;136(1):49-52. doi: 10.1023/a:1026036829237.

Abstract

We measured serum content of autoantibodies to beta-amyloid protein Abeta(1-42), its neurotoxic fragment Abeta(25-35), vasopressin, bradykinin, thrombin, antithrombin III, alpha(2)-macroglobulin, and angiotensin II in patients with various forms of Alzheimer's dementias, including presenile and senile dementias of the Alzheimer type. The ratio of antibradykinin and anti-Abeta(1-42) autoantibody contents differed by 39% in these patients. Our results can be used for the development of a new biochemical method for differential diagnostics of dementias of the Alzheimer type.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / immunology
  • Alzheimer Disease / metabolism*
  • Amyloid beta-Peptides / chemistry*
  • Antithrombin III / chemistry
  • Autoantibodies / blood*
  • Bradykinin / chemistry*
  • Humans
  • Middle Aged
  • Neurotoxins / chemistry
  • Peptide Fragments / chemistry*
  • Peptides / chemistry
  • Thrombin / chemistry
  • Vasopressins / chemistry
  • alpha-Macroglobulins / chemistry

Substances

  • Amyloid beta-Peptides
  • Autoantibodies
  • Neurotoxins
  • Peptide Fragments
  • Peptides
  • alpha-Macroglobulins
  • amyloid beta-protein (1-42)
  • amyloid beta-protein (25-35)
  • Vasopressins
  • Antithrombin III
  • Thrombin
  • Bradykinin