Abstract
[reaction: see text] Lactose-appended cyclodextrin derivatives have been synthesized and threaded onto hydrophobic polymers in aqueous solution to form dynamic multivalent lactosides for binding to lectins. The threading process, which proceeds quickly, can be observed by one- and two-dimensional NMR spectroscopies.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Carbohydrate Conformation
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Carbohydrate Sequence
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Cyclodextrins / chemical synthesis*
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Cyclodextrins / chemistry
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Cyclodextrins / metabolism
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Glycosides / chemistry*
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Lectins / metabolism
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Magnetic Resonance Spectroscopy
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Molecular Sequence Data
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Polymers / chemistry*
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Thermodynamics
Substances
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Cyclodextrins
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Glycosides
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Lectins
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Polymers
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lactosides