Identification of potent and novel small-molecule inhibitors of caspase-3

Bioorg Med Chem Lett. 2003 Nov 3;13(21):3651-5. doi: 10.1016/j.bmcl.2003.08.024.

Abstract

The design and synthesis of a series of novel, reversible, small molecule inhibitors of caspase-3 are described.

MeSH terms

  • Aldehydes / chemistry
  • Caspase 3
  • Caspase Inhibitors*
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology*
  • Indicators and Reagents
  • Ketones / chemistry
  • Kinetics
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Molecular Conformation
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • Aldehydes
  • Caspase Inhibitors
  • Enzyme Inhibitors
  • Indicators and Reagents
  • Ketones
  • Caspase 3