Abstract
Thioacetal artemisinin derivatives, in particular, 10alpha-phenylthiodihydroartemisinins (5), 10beta-benzenesulfonyl-9-epi-dihydroartemisinin (9) and 10alpha-mercaptodihydroartemisinin (11), exhibit good growth inhibition activity against HUVEC proliferation at the concentration level of 1 microM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetals / chemical synthesis*
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Acetals / pharmacology
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Artemisinins / chemical synthesis*
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Artemisinins / pharmacology
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Cell Division / drug effects
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Colorimetry
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Endothelial Cells / drug effects*
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Female
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Humans
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Lactones / chemical synthesis*
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Lactones / pharmacology
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Pregnancy
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Sesquiterpenes / chemical synthesis*
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Sesquiterpenes / pharmacology
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Structure-Activity Relationship
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Tetrazolium Salts
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Thiazoles
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Umbilical Veins / cytology
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Umbilical Veins / drug effects
Substances
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Acetals
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Artemisinins
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Lactones
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Sesquiterpenes
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Tetrazolium Salts
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Thiazoles
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thiazolyl blue
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artemisin