Abstract
A crude chloroform extract of seeds of Millettia dura Dunn (Leguminosae) showed high activity (LC50 = 3.5 microg ml(-1) at 24 h) against second-instar larvae of the mosquito, Aedes aegypti L (Diptera: Culicidae). The rotenoids, deguelin and tephrosin, isolated from the seeds of this plant also showed potent activities, with LC50 values of 1.6 and 1.4 microg ml(-1) at 24 h, respectively. The related rotenoids millettone and millettosin were inactive at 20 microg ml(-1). Saturation at the B/C ring junction and the presence of methoxy groups at C-2 and/or C-3 in deguelin and tephrosin appear to be important for the observed larvicidal activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aedes / drug effects*
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Animals
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Chromones / chemistry
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Chromones / isolation & purification
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Chromones / toxicity*
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Dose-Response Relationship, Drug
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Insecticides / chemistry
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Insecticides / isolation & purification
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Insecticides / toxicity*
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Larva / drug effects
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Millettia / chemistry*
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Molecular Structure
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / toxicity
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Pyrans / chemistry
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Pyrans / isolation & purification
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Pyrans / toxicity*
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Rotenone / analogs & derivatives*
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Rotenone / chemistry
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Rotenone / isolation & purification
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Rotenone / toxicity*
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Seeds / chemistry*
Substances
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Chromones
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Insecticides
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Plant Extracts
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Pyrans
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millettosin
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Rotenone
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millettone
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tephrosin
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deguelin