Abstract
A novel water-soluble paclitaxel complex has been prepared by inclusion complexation with bridged bis(beta-cyclodextrin)s and characterized by means of (1)H NMR, SEM, powder X-ray diffraction patterns, TG-DTA, DSC, FT-IR, and 2D NOESY. The cyclodextrins were able to solubilize paclitaxel to levels as high as 2 mg/mL. Furthermore, the cytotoxicity of the novel complexes was assessed using a K562 leukemia cell line which indicated that drug concentrations of 10 pg/mL elicited an inhibitory effect.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry*
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Bridged-Ring Compounds / chemistry*
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Calorimetry, Differential Scanning
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Cyclodextrins / chemistry*
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Magnetic Resonance Spectroscopy
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Microscopy, Electron, Scanning
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Models, Molecular
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Paclitaxel / chemistry*
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Polyamines / chemistry*
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Spectroscopy, Fourier Transform Infrared
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Thermogravimetry
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X-Ray Diffraction
Substances
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Antineoplastic Agents
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Bridged-Ring Compounds
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Cyclodextrins
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Polyamines
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Paclitaxel