Bi- and tricyclic nucleoside derivatives restricted in S-type conformations and obtained by RCM-reactions

Nanna Albaek; Jacob Ravn; Morten Freitag; Helena Thomasen; Nanna K Christensen; Michael Petersen; Poul Nielsen

doi:10.1081/NCN-120022619

Bi- and tricyclic nucleoside derivatives restricted in S-type conformations and obtained by RCM-reactions

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):723-5. doi: 10.1081/NCN-120022619.

Authors

Nanna Albaek¹, Jacob Ravn, Morten Freitag, Helena Thomasen, Nanna K Christensen, Michael Petersen, Poul Nielsen

Affiliation

¹ Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Odense M, Denmark.

PMID: 14565263
DOI: 10.1081/NCN-120022619

Abstract

Ring-closing metathesis (RCM) is applied as a new and powerful technology in the construction of nucleoside analogues that are conformationally restricted in S-type conformations due to additional 3',4'- and/or 3',5'-linkages.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chemistry, Organic / methods
Models, Molecular
Molecular Conformation
Nucleosides / chemical synthesis*
Nucleosides / chemistry*

Substances

Nucleosides