Alpha-LNA (alpha-D-configured locked nucleic acid)

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1143-5. doi: 10.1081/NCN-120022821.

Abstract

Two pyrimidine alpha-LNA nucleoside monomers have been synthesised and incorporated into alpha-configured oligonucleotides. A fully modified mixed alpha-LNA sequence displays unprecedented parallel stranded hybridisation with complementary RNA and a remarkable selectivity for RNA over DNA. Modelling shows alpha-LNA:RNA to form an extended duplex with a very broad major groove.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • DNA / chemistry
  • Nucleic Acid Conformation
  • Nucleic Acid Hybridization
  • Oligonucleotides
  • Oligonucleotides, Antisense / chemistry*
  • Pyrimidines*
  • RNA / chemistry*

Substances

  • Oligonucleotides
  • Oligonucleotides, Antisense
  • Pyrimidines
  • locked nucleic acid
  • RNA
  • DNA