The cleavage of the triphosphate bridge of a model for the 5'-cap mRNA promoted by dinuclear bicyclic complexes with metal ions

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1391-3. doi: 10.1081/NCN-120022993.

Abstract

Dinuclear bicyclic complexes, which have two active centers, can significantly promote the hydrolysis of the triphosphate bridge in ApppA, a 5'-cap model compound.

MeSH terms

  • Bridged Bicyclo Compounds
  • Cations, Divalent
  • Copper*
  • Dinucleoside Phosphates / chemistry*
  • Hydrolysis
  • Kinetics
  • RNA Caps / chemistry*
  • RNA Caps / genetics
  • RNA, Messenger / genetics
  • Transcription, Genetic

Substances

  • Bridged Bicyclo Compounds
  • Cations, Divalent
  • Dinucleoside Phosphates
  • RNA Caps
  • RNA, Messenger
  • diadenosine triphosphate
  • Copper