Abstract
A novel apio analogue of neplanocin A was efficiently synthesized from D-ribose via stereoselective aldol-retroaldol reaction for introducing hydroxymethyl group and RCM reaction for synthesizing carbocycle, and its inhibitory activity against SAH hydrolase was assayed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine / analogs & derivatives
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Adenosine / chemical synthesis*
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Adenosine / chemistry
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Adenosine / pharmacology
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Adenosylhomocysteinase / antagonists & inhibitors*
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Drug Design
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Enzyme Inhibitors / chemical synthesis*
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Indicators and Reagents
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Molecular Structure
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Structure-Activity Relationship
Substances
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Enzyme Inhibitors
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Indicators and Reagents
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neplanocin A
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Adenosylhomocysteinase
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Adenosine