Sequence of HA gene of avian influenza A/Chicken/Guangdong/SS/1994 (H9N2) virus

Avian Dis. 2003;47(3 Suppl):1118-21. doi: 10.1637/0005-2086-47.s3.1118.

Abstract

The RNA of the hemagglutinin (HA) gene of A/Chicken/Guangdong/SS/1994 (H9N2) was reverse transcription-polymerase chain reaction amplified, and the cDNA was cloned into a plasmid vector. The complete coding sequence of the HA gene was sequenced and included 1683 nucleotides, which encoded for a protein of 560 amino acids. The potential glycosylation sites related to HA protein function were highly conserved. The amino acid sequence of the HA proteolytic cleavage was G-S-S-R/G. This cleavage site sequence is compatible with a low-pathogenic avian influenza virus. Sequence comparison of this HA gene with other H9 influenza virus sequences in the GenBank database showed a 82%-97% nucleotide and amino acid sequence similarity.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chickens
  • China
  • Cloning, Molecular
  • Genes, Viral
  • Hemagglutinin Glycoproteins, Influenza Virus / chemistry
  • Hemagglutinin Glycoproteins, Influenza Virus / genetics*
  • Influenza A Virus, H9N2 Subtype*
  • Influenza A virus / genetics*
  • Molecular Sequence Data
  • RNA, Viral / genetics
  • RNA, Viral / isolation & purification
  • Recombinant Proteins / chemistry
  • Reverse Transcriptase Polymerase Chain Reaction
  • Viral Structural Proteins / genetics

Substances

  • Hemagglutinin Glycoproteins, Influenza Virus
  • RNA, Viral
  • Recombinant Proteins
  • Viral Structural Proteins