Comparison of gallium-67 citrate and technetium-99m tetrofosmin scan to detect Hodgkin's disease

Ann Nucl Med. 2003 Sep;17(6):439-42. doi: 10.1007/BF03006431.

Abstract

Objective: The purpose of this study was to compare the usefulness of gallium-67 citrate (67Ga) and technetium-99m tetrofosmin (Tc-TF) scan to detect Hodgkin's disease (HD).

Methods: In this study, 24 patients with HD underwent 67Ga and Tc-TF scan before receiving any therapy.

Results: 67Ga scan could detect HD in all 24 (100%) patients. Tc-TF scan could detect HD in 22/24 (91.6%) patients, but it was false-negative in one case of infradiaphragmatic HD and in another case with chemotherapy resistance. There was no significant difference in detection sensitivity between 67Ga and Tc-TF scan.

Conclusions: We conclude that Tc-TF scan can not replace conventional 67Ga scan to detect HD.

Publication types

  • Clinical Trial
  • Comparative Study
  • Validation Study

MeSH terms

  • Adult
  • Age Factors
  • Citrates*
  • False Negative Reactions
  • Female
  • Gallium*
  • Hodgkin Disease / diagnostic imaging*
  • Hodgkin Disease / pathology
  • Humans
  • Male
  • Middle Aged
  • Organophosphorus Compounds*
  • Organotechnetium Compounds*
  • Radionuclide Imaging
  • Radiopharmaceuticals
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Sex Factors
  • Whole-Body Counting / methods*

Substances

  • Citrates
  • Organophosphorus Compounds
  • Organotechnetium Compounds
  • Radiopharmaceuticals
  • technetium tc-99m tetrofosmin
  • Gallium
  • gallium citrate