Abstract
Two new lactones, litsealactone A (1) and litsealactone B (2), were isolated from the leaves of Litsea japonica, together with three known lactones, hamabiwalactone A (3), hamabiwalactone B (4), and akolactone B (5). Hamabiwalactone B (4) and akolactone B (5) significantly inhibited complement activity in an in vitro anti-complement assay, with IC(50) values of 149 and 58 muM, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Complement Inactivator Proteins / chemistry
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Complement Inactivator Proteins / isolation & purification*
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Complement Inactivator Proteins / pharmacology
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Inhibitory Concentration 50
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Korea
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Lactones / chemistry
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Lactones / isolation & purification*
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Lactones / pharmacology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
Substances
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Complement Inactivator Proteins
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Lactones