Abstract
The total synthesis of wedelolactone, a naturally occurring direct inhibitor of IKK complex that can suppress LPS-induced caspase-11 expression, using a convergent synthetic approach, is described. The key steps involved in this synthesis include the palladium-catalyzed Sonogashira reaction and the palladium-catalyzed carbonylative annulation reaction. This approach allows access to diversified analogues of wedelolactone.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Carrier Proteins / antagonists & inhibitors
-
Carrier Proteins / chemistry
-
Caspase Inhibitors
-
Caspases / chemistry
-
Coumarins / chemical synthesis*
-
Coumarins / pharmacology
-
Intracellular Signaling Peptides and Proteins
-
Lipopolysaccharides / antagonists & inhibitors
-
Magnetic Resonance Spectroscopy
-
Palladium / chemistry
-
Structure-Activity Relationship
Substances
-
Carrier Proteins
-
Caspase Inhibitors
-
Coumarins
-
Ikbkap protein, mouse
-
Intracellular Signaling Peptides and Proteins
-
Lipopolysaccharides
-
wedelolactone
-
Palladium
-
Caspases