Mild electrophilic trifluoromethylation of beta-ketoesters and silyl enol ethers with 5-trifluoro methyldibenzothiophenium tetrafluoroborate

J Org Chem. 2003 Oct 31;68(22):8726-9. doi: 10.1021/jo034881e.

Abstract

Cyclic and acyclic beta-ketoesters were efficiently trifluoromethylated with 5-trifluoromethyldibenzothiophenium tetrafluoroborate in the presence of a phase-transfer catalyst to afford the corresponding alpha-substituted alpha-trifluoromethyl beta-ketoesters in good to excellent yields. In a second approach, 5-trifluoromethyldibenzothiophenium tetrafluoroborate and tetrabutylammonium difluorotriphenylstannate were used for efficient electrophilic trifluoromethylation of various silyl enol ethers leading to the corresponding alpha-trifluoromethyl ketones in good to high yields.