Genetic relatedness of recently collected Spanish respiratory tract Streptococcus pneumoniae isolates with reduced susceptibility to amoxicillin

E Pérez-Trallero; J M Marimón; A González; C García-Rey; L Aguilar

doi:10.1128/AAC.47.11.3637-3639.2003

Genetic relatedness of recently collected Spanish respiratory tract Streptococcus pneumoniae isolates with reduced susceptibility to amoxicillin

Antimicrob Agents Chemother. 2003 Nov;47(11):3637-9. doi: 10.1128/AAC.47.11.3637-3639.2003.

Authors

E Pérez-Trallero¹, J M Marimón, A González, C García-Rey, L Aguilar

Affiliation

¹ Microbiology Department, Hospital Donostia, San Sebastián, Spain. [email protected]

Abstract

Of Streptococcus pneumoniae isolates from 17 hospitals, 9.8% were amoxicillin nonsusceptible (MIC > or = 4 microg/ml). The genetic relatedness of 138 isolates was studied by pulsed-field gel electrophoresis. Although 44 different clones were detected, more than 62% of these isolates were related to four clones (Spain(23F)-1, Spain(6B)-2, Spain(9V)-3, and Spain(14)-5).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amoxicillin / pharmacology*
Cloning, Molecular
DNA, Bacterial / genetics
Drug Resistance, Bacterial
Drug Resistance, Multiple, Bacterial / genetics
Electrophoresis, Gel, Pulsed-Field
Humans
Microbial Sensitivity Tests
Penicillin Resistance / genetics*
Pneumococcal Infections / microbiology*
Respiratory Tract Infections / microbiology*
Reverse Transcriptase Polymerase Chain Reaction
Spain
Streptococcus pneumoniae / drug effects
Streptococcus pneumoniae / genetics*

Substances

DNA, Bacterial
Amoxicillin