Abstract
Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram (EEG) effect was combined with intracerebral glutamate determinations using microdialysis for rats receiving norfloxacin intravenously (150 mg/kg of body weight). The EEG effect (accompanied by tremors and seizures) was consistently observed without glutamate level modifications. Therefore, norfloxacin-inducted seizures are not triggered by intracerebral glutamate level enhancement.
MeSH terms
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Animals
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Anti-Infective Agents / pharmacokinetics
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Anti-Infective Agents / toxicity*
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Area Under Curve
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Brain Chemistry / drug effects*
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Electroencephalography / drug effects*
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Glutamic Acid / metabolism*
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Hippocampus / drug effects
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Hippocampus / metabolism
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Male
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Microdialysis
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Norfloxacin / pharmacokinetics
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Norfloxacin / toxicity*
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Rats
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Rats, Sprague-Dawley
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Seizures / chemically induced*
Substances
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Anti-Infective Agents
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Glutamic Acid
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Norfloxacin