Abstract
Significant differences between animal and human pharmacokinetics may be responsible for the conflicting results of experimental studies. This study determined the impact of human pharmacokinetic simulation (HPS) on gentamicin activity in an Enterococcus faecalis endocarditis model. The decrease in bacterial counts was greater with HPS than with a dose-equivalent regimen without HPS.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / pharmacokinetics*
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Anti-Bacterial Agents / therapeutic use*
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Area Under Curve
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Colony Count, Microbial
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Disease Models, Animal
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Endocarditis, Bacterial / drug therapy*
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Endocarditis, Bacterial / microbiology
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Enterococcus faecalis*
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Female
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Gentamicins / pharmacokinetics*
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Gentamicins / therapeutic use*
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Gram-Positive Bacterial Infections / drug therapy*
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Gram-Positive Bacterial Infections / microbiology
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Half-Life
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Rabbits
Substances
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Anti-Bacterial Agents
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Gentamicins