Objective: To investigate the expression and the significance of main heat stress proteins (HSPs) and p53 in nasopharyngeal carcinoma.
Method: Tissues homogenate and western blot were used to determine the level of HSPs and p53.
Result: HSP27 and p53 elevated remarkably (P < 0.05) while HSP90 and HSP70 showed no significance between nasopharyngeal carcinoma and control tissues. Elevated level of HSP27 and p53 don't correlated with histological type and clinical stage.
Conclusion: Expression of HSPs and p53 show some difference in nasopharyngeal carcinoma tissue. These data suggest that HSPs and p53 may play a role in the development of nasopharyngeal carcinoma.