Adding facets to TNF signaling. The JNK angle

Mol Cell. 2003 Oct;12(4):795-6. doi: 10.1016/s1097-2765(03)00399-x.

Abstract

In the October 3 issue of Cell, Deng et al. (2003) report that a JNK-dependent mitochondrial signal, the release of Smac/DIABLO, is required for TNF-induced caspase 8 activation and apoptosis. This process is interceded by a novel processed form of the BH3 only protein Bid.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Apoptosis Regulatory Proteins
  • Carrier Proteins / physiology
  • Caspase 8
  • Caspase 9
  • Caspases / physiology
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • JNK Mitogen-Activated Protein Kinases
  • Mitochondrial Proteins / physiology
  • Mitogen-Activated Protein Kinases / physiology*
  • Signal Transduction / physiology*
  • Tumor Necrosis Factor-alpha / physiology*

Substances

  • Apoptosis Regulatory Proteins
  • Carrier Proteins
  • DIABLO protein, human
  • Intracellular Signaling Peptides and Proteins
  • Mitochondrial Proteins
  • Tumor Necrosis Factor-alpha
  • JNK Mitogen-Activated Protein Kinases
  • Mitogen-Activated Protein Kinases
  • CASP8 protein, human
  • CASP9 protein, human
  • Caspase 8
  • Caspase 9
  • Caspases