Abstract
Efficient delivery of therapeutic and diagnostic agents across the plasma membrane is crucial in developing novel therapies. Membrane permeating peptides, in particular HIV-1 tat peptide and its derivatives, have enabled the intracellular delivery of cargos of various sizes and physicochemical properties. This review summarizes the current knowledge of tat-derived cell permeating peptides in the transduction of exogenous molecules/complexes.
Copyright 2003 Wiley Periodicals, Inc.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Biological Transport, Active / physiology
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Cell Membrane / metabolism
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Cell Membrane Permeability
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Drug Delivery Systems
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Gene Products, tat / metabolism*
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Humans
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Nucleic Acids / metabolism
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Peptide Fragments / metabolism*
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Protein Transport / physiology*
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tat Gene Products, Human Immunodeficiency Virus
Substances
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Gene Products, tat
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Nucleic Acids
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Peptide Fragments
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tat Gene Products, Human Immunodeficiency Virus
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tat peptide (48-60), Human immunodeficiency virus 1