Abstract
Two new phenanthroquinolizidine alkaloids, boehmeriasins A and B, were isolated from the aqueous ethanolic extract of Boehmeria siamensis Craib (Urticaceae) by bioassay-guided fractionation. Their structures were elucidated on the basis of spectral evidence. Boehmeriasin A possesses cytotoxic activity against 12 cell lines from 6 panels of cancer including lung cancer, colon cancer, breast cancer, prostate cancer, kidney cancer and leukemia with GI (50) between 0.2 and 100 ng/mL, whereas boehmeriasin B showed lower activity.
MeSH terms
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Alkaloids / administration & dosage
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Alkaloids / pharmacology
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Alkaloids / therapeutic use
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Antineoplastic Agents, Phytogenic / administration & dosage
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Antineoplastic Agents, Phytogenic / pharmacology*
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Antineoplastic Agents, Phytogenic / therapeutic use
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Boehmeria*
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Cell Line, Tumor / drug effects
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Dose-Response Relationship, Drug
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Humans
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Inhibitory Concentration 50
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Paclitaxel / pharmacology
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Phenanthrenes / administration & dosage
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Phenanthrenes / pharmacology
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Phenanthrenes / therapeutic use
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Quinolizidines / administration & dosage
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Quinolizidines / pharmacology
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Quinolizidines / therapeutic use
Substances
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Phenanthrenes
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Plant Extracts
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Quinolizidines
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boehmeriasin A
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Paclitaxel