Abstract
An optimal antitumoral immune response requires the activation of both CD8(+) and CD4(+) T lymphocytes by the peptide antigen presentation via the human leukocyte antigen (HLA) class I and class II molecules, respectively. Downregulation or loss of HLA molecules has been found in human renal cell carcinoma (RCC) and provides a strategy of these tumors to evade T-cell mediated immunosurveillance. In addition, a tumor-specific upregulation of HLA-G has been recently described in RCC, which also leads to an impaired immune response. We here summarize the frequency of the constitutive and/or interferon-gamma (IFN-gamma) inducible expression of nonclassical HLA class Ib antigens in RCC cell lines, surgically removed RCC lesions and normal kidney epithelium, the molecular characteristics of HLA-G expression, and its role in immune recognition.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Monoclonal
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Blotting, Southern
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Blotting, Western
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Carcinoma, Renal Cell / genetics
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Carcinoma, Renal Cell / immunology*
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Carcinoma, Renal Cell / metabolism
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Flow Cytometry
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Gene Expression Regulation, Neoplastic
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HLA Antigens / biosynthesis
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HLA Antigens / genetics*
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HLA Antigens / immunology*
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HLA-G Antigens
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Histocompatibility Antigens Class I / biosynthesis
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Histocompatibility Antigens Class I / genetics*
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Histocompatibility Antigens Class I / immunology*
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Humans
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Interferon-gamma / pharmacology
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Kidney Neoplasms / genetics
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Kidney Neoplasms / immunology*
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Kidney Neoplasms / metabolism
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Killer Cells, Natural / immunology
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RNA, Messenger / biosynthesis
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RNA, Messenger / genetics
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Recombinant Proteins
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Reverse Transcriptase Polymerase Chain Reaction
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T-Lymphocytes, Cytotoxic / immunology
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Tumor Cells, Cultured
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Up-Regulation
Substances
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Antibodies, Monoclonal
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HLA Antigens
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HLA-G Antigens
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Histocompatibility Antigens Class I
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RNA, Messenger
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Recombinant Proteins
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Interferon-gamma